pentobarbital will lessen the level or influence of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Decreased AUC of tramadol and also the active metabolite (O-desmethyltramadol) when coadministered with sturdy CYP3A4 and CYP2B6 inducerspentobarbital will lower the level or effect of clarithromycin by a… Read More